Technology Development

Patent Pending ‘Optoelectronic Remotely Powered Silicon-based Hybrid Neural Electrode’, US Provisional Patent Application No. 61/509,920

Filed July 20, 2011, Pending

One aspect of the invention provides an optically powered, integrated wireless neural electrode-telemetry module comprising (a) porous silicon wafer; (b) at least one neural electrode; (c) a low noise pre-amplifier; (d) an optical power converter; (e) a signal processor; and (f) a radio-frequency (RF) transmitter microchip. Another aspect of the invention provides a method of chronically recording electrical activity from a single neuron in vivo. The method comprises implanting an optically powered, integrated wireless neural electrode-telemetry module into the brain or spinal cord of a subject.

Patent Pending ‘Neuronal Mechanisms Underlying Seizure Generation in an Animal Model of Chronic Epilepsy’, US Provisional Patent Application No. 61/492,173

Filed June 1, 2011, Pending

Abstract: The present invention describes systems and methods for predicting and detecting a seizure in a subject. The methods of the invention comprise measuring interneuron synchrony in terms of the coherence between interneuron action potentials and local field potential oscillations. In one embodiment, the detection of specific patterns of coherence, correlation, and firing rate of interneurons predicts an upcoming seizure.

Patent Pending ‘Chronic, In-vivo Neurotransmitter Sensor’, US Patent Application No. 11/879,616

Filed July 18, 2007, pending

Abstract: Carbon-coated ceramic based electrode arrays having a ceramic substrate patterned with multiple recording sites are provided. Potentiostat devices having said carbon-coated ceramic based electrodes, and methods of use, are also provided. Certain embodiments of the present inventive articles, devices, and methods are especially suited for detection and/or measurement of electroactive species.

Patent Awarded ‘Wireless Controlled Neuromodulation System’, US Patent No. 8,086,316

Filed May 24, 2007, Awarded September 6, 2011

Abstract: An apparatus is disclosed for controlled neuromodulation. The apparatus includes a plurality of neural sensors, wherein each of the neural sensors is electrically connected to a separate signal conditioner. Each of the signal conditioners produces a neural sensor signal, which is analyzed by a separate threshold detector to produces a neural event signal when the neural sensor signal exceeds a threshold level associated with the threshold detector. Each of the threshold detectors is connected to a wireless transceiver and the wireless transceivers transmit the neural event signals to a processor. The processor analyzes the neural event signals and determines the presence or absence of a clinical brain state. The apparatus can be used to detect and control epileptic seizures.

Patent Pending 'Method to quantitatively measure effect of psychotropic drugs on sensory discrimination', Serial No. 60/760,211

Filed Date January 19, 2006, Pending

Abstract: A method for evaluating an effect of a psychotropic compound or a treatment on a neuronal activity of an animal including determining a change in the amount of information generated by neurons in response to at least one repeatedly applied stimulus, wherein the change is caused by administering the psychotropic compound or a treatment. Also provided is a method of screening psychotropic compounds for effectiveness on an animal which involves using a change in sensory discrimination in a population of neurons of the animal, wherein the sensory discrimination is obtained in response to one or more stimuli repeatedly applied to the animal and wherein a change in the sensory discrimination occurs due to administering said psychotropic compounds to the animal.

Patent Awarded 'Ceramic based multi-site electrode arrays and methods for their production', US Patent No. 6,834,200

Filed October 19, 2001, Awarded Dec 21, 2004

Abstract: Ceramic based multi-site electrode arrays of a polished ceramic substrate patterned with recording sites and bonding pads which are connected via conducting lines are provided. Methods for producing these electrode arrays and using the electrode arrays to record or stimulate multiple neurons in a mammal are also provided.