throckmorton Pictured above, P.I. Amy L. Throckmorton, PhD

Longer-term mechanical circulatory assist will provide an improved quality of life for thousands of pediatric patients per year in the United States who suffer from ventricular failure secondary to acquired or congenital heart disease. There are currently very few mechanical circulatory support systems available as viable bridge-to-transplant or recovery alternatives.

To address this substantial need, we are developing alternative biodevices to augment circulatory flow and pressure in these pediatric patients with biventricular or univentricular physiology. Noninvasive, minimally invasive, and invasive technologies are being designed, developed, and evaluated in this laboratory.

Our research group constitutes an ideal multidisciplinary team to carry out this line of research and bench-to-bedside device development. These biomechanical devices will become an effective therapeutic option for thousands of infants and children suffering from heart failure in the United States - ultimately saving lives and addressing a significant human health problem.

Recent News

newlab The BioCirc Lab is located in the state-of-the-art Edmund D. Bossone Research Enterprise Center in the School of Biomedical Engineering, Science and Health Systems at Drexel University. Located in downtown Philadelphia, this urban academic and research facility provides cutting edge resources, producing research at the forefront of technology. The155,000-square-foot multistory has 48 teaching laboratories, 37 lab support spaces, 77 offices, and a 300-seat auditorium. The BioCirc Lab consists of a 600 square foot lab space that is equipped with instrumentation and equipment to conduct computer modeling, experimental testing of prototypes, hemolysis testing, and statistical analyses of data acquired in the development of innovative treatment options for pediatric and adult patients with heart failure.

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Recent Publication:

Support for Fontan Physiology

A.L. Throckmorton, S. Lopez-Isaza, E.A. Downs, S.G. Chopski, J.J. Gangemi, and W.B. Moskowitz.

"Viable Therapeutic Option: Mechanical Circulatory Support of the Failing Fontan Physiology."

Pediatr Cardiol 2013; 34(6): 1357-65.